GEO series
BMAL2 controls adipose tissue inflammation and metabolic adaptation during obesity
GSE289800
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/09/21
GPL19057
Summary
We profile the transcripts of adipose progenitors defined as CD45-CD31-PDGFRb+ isolated from eWAT of wild-type and Bmal2-/- C57BL/6J mice fed with normal diet or high-fat diet for 12 weeks. We show that Bmal2 invalidation strongly impacts the transcriptome profile in adipose progenitors and, when associated with obesogenic diet, enhances its deleterious effects. Loss of Bmal2 alters metabolic and maintenance pathways in adipose progenitors and strongly enhances their inflammatory function during diet-induced obesity.
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