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Sox6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy

GSE290130 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/11/14 Platform GPL24247
Summary
Background: Sox6 has been shown to play a crucial role in the development of the cardiovascular system. However, its potential role in hypertension and vascular function remains unclear. Methods: In vascular smooth muscle cells (VSMCs), we employed gain- and loss-of-function approaches combined with RNA sequencing, autophagy flux assessment, and phenotype characterization. Additionally, we established a mouse model with Sox6 overexpression via adeno-associated virus 2 (AAV2) to validate the findings in vivo. Conclusions: Our findings revealed that Sox6 regulates VSMC plasticity and elevates blood pressure by activating autophagy. Therefore, Sox6 inhibition potentially represents a novel strategy for treating hypertension and vascular remodeling.
Published in
SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy
Ling Q, Dong X, Mao L et al. · Animal models and experimental medicine 2025 · PMID 40501408 · doi:10.1002/ame2.70046
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Also filed as BioProject PRJNA1226239 and SRA study SRP565332. Searching any of these in the dataset finder brings you back here.

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