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Rbfox2-dependent alternative splicing of Numb regulates Notch signaling during muscle stem cell activation II

GSE290586 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/30 Platform GPL28330
Summary
Satellite cells (SCs), or muscle stem cells, are the resident somatic stem cells responsible for skeletal muscle regeneration. Most SCs remain quiescent in resting adult muscles but can activate rapidly upon receiving a stimulus. While alternative splicing has been reported to play important role in stem cells , its role in the activation process of SCs remains elusive. We identified Numb as one of the genes that display rapid splicing change during SC activation. To investigate the role of Numb splicing during satellite cell activation, we use morpholino to inhibit the inculstion of Numb exon 6 on early activated SCs and performed RNA-seq to profile the transcriptome changes upon Numb splicing change.
Published in
RBFOX2-dependent alternative splicing of Numb regulates Notch signaling during muscle stem cell activation
Lin K, Liu J, Tse EHY et al. · Stem cell reports 2026 · PMID 41418788 · doi:10.1016/j.stemcr.2025.102745
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Also filed as BioProject PRJNA1228669 and SRA study SRP566531. Searching any of these in the dataset finder brings you back here.

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