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Muribaculum intestinale negatively impacts glioma growth in mice through the toll-like receptor 2

GSE290960 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/11 Platform GPL34328
Summary
Glioblastoma (GBM) is the most common and malignant brain tumor in adult humans. Recent studies have demonstrated a link between the composition of the gut microbiota and glioma progression. Here, we describe that the growth of glioma in mice is inversely correlated with the relative abundance of the anaerobic bacterium Muribaculum intestinale in the feces. We found that M. intestinale administration: 1) induced an inflammatory environment in the gut; 2) reduced glioma growth; 3) increased the pro-inflammatory profile of tumor-associated microglial cells and the frequency of CD8+ T cells; and 4) increased the peripheral TNF-α levels. The effects induced by M. intestinale administration were significantly reduced upon toll-like receptor 2 (TLR2) silencing using siRNA targeting TLR2. These receptors recognise microbial patterns and control immune responses to infection. Collectively, these data demonstrate that M. intestinale induces a pro-inflammatory response in glioma bearing mice, inhibiting tumor growth via TLR2-dependent signaling.
Published in
Muribaculum intestinale negatively impacts glioma growth in mice through the toll-like receptor 2
Marrocco F, Cocozza G, Antonangeli F et al. · Gut microbes 2026 · PMID 41612972 · doi:10.1080/19490976.2026.2623349
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Also filed as BioProject PRJNA1231087 and SRA study SRP567653. Searching any of these in the dataset finder brings you back here.

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