Human cytomegalovirus induces neuronal gene expression to promote virion maturation in macroH2A1-dependent manner
RNA-seq (gene expression) · human · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Human cytomegalovirus induces neuronal gene expression through IE1 for viral maturationNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291064_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1231484 and SRA study SRP567853. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 5 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8828427 IE1_deltaCTD Rep1 IE1_deltaCTD
- GSM8828428 IE1_deltaCTD Rep2 IE1_deltaCTD
- GSM8828429 IE1_deltaCTD Rep3 IE1_deltaCTD
- GSM8828430 IE1 Rep1 IE1
- GSM8828431 IE1 Rep2 IE1
- GSM8828432 IE1 Rep3 IE1
- GSM8828433 IE2 Rep1 IE2
- GSM8828434 IE2 Rep2 IE2
- GSM8828435 IE2 Rep3 IE2
- GSM8828436 Luciferase Rep1 Luciferase
- GSM8828437 Luciferase Rep2 Luciferase
- GSM8828438 Luciferase Rep3 Luciferase
- GSM8828439 MRC5 no Dox Control Rep1 MRC5 no Dox Control
- GSM8828440 MRC5 no Dox Control Rep2 MRC5 no Dox Control
- GSM8828441 MRC5 no Dox Control Rep3 MRC5 no Dox Control
- GSE285570 Transcriptional regulation of temporal dynamics in human neurogenesis and neuronal maturation [RNA-seq] 50 samples shares maturation, neuronal
- GSE244435 Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation 48 samples shares neuronal, induces
- GSE278512 Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity 45 samples shares maturation, promote
- GSE319314 Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model 23 samples shares maturation, neuronal
- GSE112648 SOXC factors as suppressors modulate Rho activity to promote neuronal reprogramming of human glioblastoma cells 18 samples shares neuronal, promote
- GSE307922 Destabilization of the noncanonical PRC1.1 complex via USP7 inhibition induces neuronal differentiation in neuroblastoma [RNA-Seq] 18 samples shares neuronal, induces
- GSE244369 All-defined NGN2 neuron protocol reveals multifaceted signatures of neuronal maturation [bulk timecourse] 15 samples shares maturation, neuronal
- GSE291635 Cell Type Differences in Human Cytomegalovirus Transcription and Epigenetic Regulation with Insights into Major Immediate-Early Enhancer-Promoter Control [RNA-seq] 12 samples shares cytomegalovirus, promote
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.