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GLP-1 receptor agonism results in reduction in hepatic ethanol metabolism

GSE291407 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/09/18 Platform GPL24247
Summary
Glucagon-like peptide 1 receptor (GLP-1R) agonists are used along with ethanol consumption, but their interactions are not understood. Our aim was to determine the effects of GLP-1R agonism on the liver in mouse models of high ethanol consumption. We identified that GLP-1R agonism reduced ethanol consumption, mitigated ethanol-induced upregulation of several liver metabolizing enzymes, including Cyp2e1 and also reduced Cyp2e1 independent of ethanol intake. As expected from a reduction in Cyp2e1, GLP-1R agonism resulted in increased blood ethanol levels. This occurred after a single dose of ethanol when given by gavage, and by the intraperitoneal route. This suggests that GLP-1R agonism can reduce ethanol-mediated hepatotoxicity despite continued ethanol consumption and elevate blood alcohol levels
Published in
GLP-1 receptor agonism results in reduction in hepatic ethanol metabolism
Zahrawi F, Suyavaran A, Banini BA et al. · npj metabolic health and disease 2025 · PMID 40968135 · doi:10.1038/s44324-025-00077-y
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Also filed as BioProject PRJNA1233313 and SRA study SRP568731. Searching any of these in the dataset finder brings you back here.

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