Transcriptional alterations in the brain following Dot1l conditional knockout using the Emx1-Cre mouse line at embryonic day 16.5 [EmxDotRNAE16]
Single-cell RNA-seq · mouse · 2 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 2 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- DNMT1-mediated regulation of somatostatin-positive interneuron migration impacts cortical architecture and functionNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291845_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1235617 and SRA study SRP570184. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 2 more — browse all 2 samples with per-sample file links →
- GSE294144 RNA sequencing - E12 mouse embryonic cortices Emx1-Cre Zbtb7a-flox cKO vs WT 10 samples shares emx1-cre, embryonic
- GSE301374 Inhibition of H3K79me2 by DOT1L inhibitor EPZ5676 promotes mouse embryonic lung branching morphogenesis via increasing epithelium proliferation 9 samples shares dot1l, embryonic
- GSE268951 Trancriptome profiling of medial frontal cortices of P28 offspring from breeding of Dnmt3l conditional knockin and Emx1-cre mice 24 samples shares emx1-cre, conditional
- GSE232415 Gene expression alterations with Nkapl knockout or NKAPL frameshift mutation (M349fs) 26 samples shares alterations, knockout
- GSE252418 Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice 83 samples shares alterations, embryonic
- GSE264514 Epigenetic and transcriptional alterations with Kmt2c and Kmt2d knockout 50 samples shares alterations, knockout
- GSE282854 Targeting the histone methyltransferase DOT1L rewires CD8 T cells and enhances their intrinsic cytotoxic activity towards tumor cells [RNAseq_WT_KO_DMSO_EPZ] 14 samples shares dot1l
- GSE222233 DOT1L controls NK cell maturation and lineage integrity [RNA-seq D0 & D2] 11 samples shares dot1l
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.