Glucocorticoid resistance during chronic social stress in mice: RNA-seq of prefrontal cortex
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 8 × RNA-seq_SDS30_sal vs 8 × RNA-seq_SDS30_dex vs 4 × RNA-seq_con_sal vs 4 × RNA-seq_con_dexGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Phenotype-Specific Transcriptomic Responses to Glucocorticoid Signaling in the Prefrontal Cortex and Dorsal Raphe Nucleus Following Chronic Social StressInternational journal of molecular sciences · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE330674_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA846517 and SRA study SRP382208. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 4 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9730165 RNA-seq_con_sal_106 RNA-seq_con_sal
- GSM9730166 RNA-seq_con_sal_107 RNA-seq_con_sal
- GSM9730167 RNA-seq_con_sal_109 RNA-seq_con_sal
- GSM9730168 RNA-seq_con_sal_117 RNA-seq_con_sal
- GSM9730169 RNA-seq_con_dex_101 RNA-seq_con_dex
- GSM9730170 RNA-seq_con_dex_108 RNA-seq_con_dex
- GSM9730171 RNA-seq_con_dex_112 RNA-seq_con_dex
- GSM9730172 RNA-seq_con_dex_122 RNA-seq_con_dex
- GSM9730173 RNA-seq_SDS30_sal_2 RNA-seq_SDS30_sal
- GSM9730174 RNA-seq_SDS30_sal_28 RNA-seq_SDS30_sal
- GSM9730175 RNA-seq_SDS30_sal_62 RNA-seq_SDS30_sal
- GSM9730176 RNA-seq_SDS30_sal_68 RNA-seq_SDS30_sal
- GSM9730177 RNA-seq_SDS30_sal_8 RNA-seq_SDS30_sal
- GSM9730178 RNA-seq_SDS30_sal_14 RNA-seq_SDS30_sal
- GSM9730179 RNA-seq_SDS30_sal_40 RNA-seq_SDS30_sal
- GSM9730180 RNA-seq_SDS30_sal_44 RNA-seq_SDS30_sal
- GSM9730181 RNA-seq_SDS30_dex_6 RNA-seq_SDS30_dex
- GSM9730182 RNA-seq_SDS30_dex_34 RNA-seq_SDS30_dex
- GSM9730183 RNA-seq_SDS30_dex_52 RNA-seq_SDS30_dex
- GSM9730184 RNA-seq_SDS30_dex_56 RNA-seq_SDS30_dex
- GSM9730185 RNA-seq_SDS30_dex_38 RNA-seq_SDS30_dex
- GSM9730186 RNA-seq_SDS30_dex_42 RNA-seq_SDS30_dex
- GSM9730187 RNA-seq_SDS30_dex_60 RNA-seq_SDS30_dex
- GSM9730188 RNA-seq_SDS30_dex_72 RNA-seq_SDS30_dex
- GSE272496 Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure 38 samples shares prefrontal, chronic, stress, cortex
- GSE191016 Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress 20 samples shares prefrontal, chronic, stress
- GSE331524 Transcriptomic analysis of hippocampus and prefrontal cortex in a mouse model of chronic radiation-induced gastrointestinal injury 12 samples shares prefrontal, chronic, cortex
- GSE293709 Transcriptome analysis in the prefrontal cortex of different ASD mouse models treated with drug 1565 samples shares prefrontal, cortex
- GSE295530 MeCP2 stabilizes the glucocorticoid system in active chromatin regions [RNA-seq] 723 samples shares glucocorticoid, rna-seq
- GSE228579 Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling 66 samples shares chronic, stress
- GSE329024 Distinct HPO axis responses to chronic unpredictable stress in young versus adult female mice 63 samples shares chronic, stress
- GSE293704 Transcriptome analysis in the prefrontal cortex of Tbr1+/K228E heterozygous mice treated with drug 60 samples shares prefrontal, cortex
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.