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Anti-CD3 mAb treatment reshapes infiltrating T and beta cells in the islets in autoimmune diabetes

GSE292313 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/24 Platform GPL24247
Summary
Anti-CD3 mAb delays or prevents type 1 diabetes (T1D) by modulating the immune mediated destruction of beta cells. Our findings described the reshaping of islet-infiltrating T cells and beta cells that lead to operational, but tenuous tolerance to autoimmune diabetes following anti-CD3 mAb treatment.
Published in
Anti-CD3 mAb treatment reshapes infiltrating T and β cells in the islets in autoimmune diabetes
Wu Y, Spurrell M, Lledó-Delgado A et al. · JCI insight 2026 · PMID 41574610 · doi:10.1172/jci.insight.192755
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Also filed as BioProject PRJNA1237897 and SRA study SRP571414. Searching any of these in the dataset finder brings you back here.

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