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SEL1L is Dispensable for ER Homeostasis and Function in Spermatogenic Cells

GSE292552 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/06 Platform GPL24247
Summary
The SEL1L-HRD1 complex is a critical component of the endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway, essential for maintaining ER homeostasis and cellular function. While the importance of SEL1L and HRD1 in various physiological processes have been reported in mice and humans, their specific functions in male germ cells remain unexplored. This study aims to investigate the role of SEL1L-HRD1 ERAD in spermatogenesis process. To achieve this, we conducted whole genome RNA sequencing to identify genes differentially regulated in testes from male germ cell specific SEL1L-deficient mice.
Published in
The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells
Tushi NJ, Zhang Z, Sun S · The Journal of biological chemistry 2025 · PMID 40412517 · doi:10.1016/j.jbc.2025.110283
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Also filed as BioProject PRJNA1240194 and SRA study SRP572153. Searching any of these in the dataset finder brings you back here.

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