Interleukin-27-adipose-derived mesenchymal stromal cell-based gene therapy attenuates inflammation in lipopolysaccharide-induced acute respiratory distress syndrome
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × ASC bearing empty vector vs 4 × ASC bearing IL27 vector vs 4 × No ASC controlGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Interleukin-27-adipose-derived mesenchymal stromal cell-based gene therapy attenuates inflammation in lipopolysaccharide-induced acute respiratory distress syndromeStem cell research & therapy · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292564_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1240220 and SRA study SRP572180. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8861528 ASC bearing empty vector Replicate 1 ASC bearing empty vector
- GSM8861529 ASC bearing empty vector Replicate 2 ASC bearing empty vector
- GSM8861530 ASC bearing empty vector Replicate 3 ASC bearing empty vector
- GSM8861531 ASC bearing empty vector Replicate 4 ASC bearing empty vector
- GSM8861532 ASC bearing IL27 vector Replicate 1 ASC bearing IL27 vector
- GSM8861533 ASC bearing IL27 vector Replicate 2 ASC bearing IL27 vector
- GSM8861534 ASC bearing IL27 vector Replicate 3 ASC bearing IL27 vector
- GSM8861535 ASC bearing IL27 vector Replicate 4 ASC bearing IL27 vector
- GSM8861536 No ASC control Replicate 1 No ASC control
- GSM8861537 No ASC control Replicate 2 No ASC control
- GSM8861538 No ASC control Replicate 3 No ASC control
- GSM8861539 No ASC control Replicate 4 No ASC control
- GSE273883 CX3CR1+ Synovial Macrophages for Barrier Restore in Rheumatoid Arthritis: A New Target for Mesenchymal Stem Cell-Based Therapy? 35 samples shares mesenchymal, cell-based
- GSE252394 Fgf9 promotes adipogenesis and reduces osteogenesis by regulating mesenchymal stromal cells differentiation in adult bone marrow 18 samples shares mesenchymal, stromal
- GSE228749 Novel ex vivo culture of purified mouse mesenchymal stromal cells reveals tissue-dependent niche heterogeneity in bone marrow and functional interaction with macrophages 12 samples shares mesenchymal, stromal
- GSE223511 Mesenchymal Stem Cell Transplantation Attenuates Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula. 11 samples shares mesenchymal, attenuates
- GSE324887 Aortic carboxypeptidase-like protein potentiates β1 integrin signaling in mesenchymal progenitors (Primary stromal cells) 6 samples shares mesenchymal, stromal
- GSE286317 Engineered mesenchymal stromal cells with bispecific polyvalent peptides suppress excessive neutrophil infiltration and boost therapy 3 samples shares mesenchymal, stromal
- GSE190762 Reversibility of long-term changes to pulmonary function post early life respiratory viral infection 144 samples shares respiratory
- GSE129401 Single cell RNA-seq analysis of Tbx4+ and Tbx4- mouse lung mesenchymal cells 93 samples shares mesenchymal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.