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Bulk RNA-seq of PD1+/- T cels from mouse hearts 7 days post MI

GSE292863 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/31 Platform GPL21103
Summary
Programmed cell death protein 1 (PD1) is crucial for adaptive immunity regulation, showing considerable effects in various diseases especially in tumor field. In order to deeply investigate the expression characteristics of PD1+ T cells in heart during myocardial infarction (MI), we firstly performed single-cell RNA sequencing (scRNA-seq) to characterize non-cardiomyocytes from mouse after MI. To further determine the activation of PD1+ T cells in MI, we sorted and sequenced PD1+ T cells accompanied with PD1- T cells in the mice heart after MI. In order to deeply investigate the function of PD1+ T cells in heart during MI, we performed single-cell RNA sequencing (scRNA-seq) to detect the change T cells from anti-IgG and anti-PD1 mouse after MI.
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Direct links to NCBI, no account and no request form: the whole study as GSE292863_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1241773 and SRA study SRP572967. Searching any of these in the dataset finder brings you back here.

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