← BioTransfer GEO Dataset Finder
GEO series

RNA sequencing in Atp7b -/- mice under high-fat diet conditions

GSE294387 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/05 Platform GPL24247
Summary
The aim of this study was to elucidate the impact of ATP7B deficiency on hepatic gene expression profiles in mice fed a high-fat diet. Systemic ATP7B-knockout (Atp7b-/-) mice on a C57BL/6J genetic background were generated via CRISPR/Cas9 technology and subjected to a high-fat, high-fructose, and high-cholesterol diet (abbreviated as high-fat diet, HFD) for 24 weeks to establish a steatohepatitis model. Hepatic gene-expression profiles were analyzed by RNA sequencing (RNA-seq). ATP7B deficiency exacerbated hepatic inflammation and fibrosis in HFD-fed mice, as revealed by RNA-seq data.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE294387_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1249371 and SRA study SRP577869. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.