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Transcriptome profiling of embryonic stem cells (mESCs) derived from B6 mouse, primitive neural stem cells (NSCs) derived from mESCs, muscle fibers, fat cells, spleen cells and thymus using RNA-sequencing.

GSE295156 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/01 Platform GPL24247
Summary
The core proeprty of cancer cells is neural stemness, which determines tumorigenicity and pluripotency. Therefore, cancer cells can differentiate along different lineages. Upon differentiation, cancer cells will lose their neural stemness and tumorigenicity. Cancer cells, embrynonic stem cells and neural stem cells are immune-privileged cells and are capable of immune evasion. We used transcriptome profiling to analyze the difference in trasncriptomes and particularly, transcription of immune related genes in a few cell types representing undifferentiated and differentiated states, because immunigenicity is the key for effective anti-tumor immunity and this relies on expression of immune related genes. This analysis generates the clue to the relationship between immune related gene expression and differentiation status of cells.
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Direct links to NCBI, no account and no request form: the whole study as GSE295156_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1253629 and SRA study SRP580320. Searching any of these in the dataset finder brings you back here.

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