Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 39 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 39 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunityCancer cell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE295309_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1254158 and SRA study SRP579623. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 23 samples.
How we read this: 10 replicated groups read from 39 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8939888 Tumor_CD45_BCG
- GSM8939889 Tumor_CD45_PBS
- GSM8939890 LSK ATAC PBS Rep 1 LSK ATAC PBS
- GSM8939891 LSK ATAC PBS Rep 2 LSK ATAC PBS
- GSM8939892 LSK ATAC PBS Rep 3 LSK ATAC PBS
- GSM8939893 LSK ATAC PBS Rep 4 LSK ATAC PBS
- GSM8939894 LSK ATAC BCG Rep 1 LSK ATAC BCG
- GSM8939895 LSK ATAC BCG Rep 2 LSK ATAC BCG
- GSM8939896 LSK ATAC BCG Rep 3 LSK ATAC BCG
- GSM8939980 RNA_PBS_R1 RNA_PBS
- GSM8939981 RNA_PBS_R2 RNA_PBS
- GSM8939982 RNA_BCG_R1 RNA_BCG
- GSM8939983 RNA_BCG_R2 RNA_BCG
- GSM8939984 ATAC_PBS_R1 ATAC_PBS
- GSM8939985 ATAC_PBS_R2 ATAC_PBS
- GSM8939986 ATAC_BCG_R1 ATAC_BCG
- GSM8939987 ATAC_BCG_R2 ATAC_BCG
- GSM8944726 PBMC_Pie_Pre_RNA
- GSM8944727 PBMC_Pie_Pre_ATAC
- GSM8944728 PBMC_Pool_Pre_RNA
- GSM8944729 PBMC_Pool_Pre_ATAC
- GSM8944730 PBMC_Post_RNA
- GSM8944731 PBMC_Post_ATAC
- GSM8944732 PBMC_Pre_RNA
- GSM8944733 PBMC_Pre_ATAC
- GSM8944734 PIE_Post_RNA
- GSM8944735 PIE_Post_ATAC
- GSM8944736 PIE_Post_1_RNA
- GSM8944737 PIE_Post_1_ATAC
- GSM8944738 PIE_Post_2_RNA
- GSM8944739 PIE_Post_2_ATAC
- GSM8945132 RNA_preBCG_R1 RNA_preBCG
- GSM8945133 RNA_postBCG_R1 RNA_postBCG
- GSM8945134 RNA_preBCG_R2 RNA_preBCG
- GSM8945135 RNA_postBCG_R2 RNA_postBCG
- GSM8945136 ATAC_preBCG_R1 ATAC_preBCG
- GSM8945137 ATAC_postBCG_R1 ATAC_postBCG
- GSM8945138 ATAC_preBCG_R2 ATAC_preBCG
- GSM8945139 ATAC_postBCG_R2 ATAC_postBCG
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- GSE228550 Reversing myeloid-derived suppressor cells mediated immunosuppression via p38α inhibition enhances immunotherapy efficacy 12 samples shares immunotherapy, enhance
- GSE327497 Localized PD-1 CAR T therapy reprograms neuroinflammation. 390 samples shares reprograms
- GSE303870 A tumor-associated macrophage-targeted immunocytokine leveraging T and NK cell synergy for potent cancer immunotherapy 223 samples shares immunotherapy
- GSE314854 Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy 102 samples shares immunotherapy
- GSE239889 VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis 52 samples shares reprograms
- GSE307471 Intratumoral bacteria are immunosuppressive and promote immunotherapy resistance in head and neck squamous cell carcinoma 33 samples shares immunotherapy
- GSE341319 Vitamin B2 Sensing by the Nuclear Receptor AhR Reprograms Hepatic Metabolism [ATAC-Seq] 20 samples shares reprograms
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.