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Single nucleus RNA sequencing of the cortex of antibiotic and vehicle treated APPPS1-21 mice

GSE295459 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/05/01 Platform GPL24247
Summary
Previously, we and others have shown that broad spectrum antibiotic treatment from postnatal day 14-21 reduces neuroinflammation in the APPPS1-21 model of AD-related amyloidosis. In the current study, we used single-nucleus RNA sequencing (snRNAseq) to assess cell-type specific transcriptional changes in antibiotic treated mice and controls. We also assessed changes in astrocyte subclusters in these groups.
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Direct links to NCBI, no account and no request form: the whole study as GSE295459_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1254715 and SRA study SRP580864. Searching any of these in the dataset finder brings you back here.

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