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Targeting Glucose Metabolism: Synergistic Strategies to Enhance Apoptosis and Immune Activation in Hepatocellular Carcinoma Treatment

GSE295520 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/30 Platform GPL34328
Summary
Exploiting the dependency of cancer cells on glycolysis offers a promising avenue to enhance therapeutic strategies for hepatocellular carcinoma (HCC). In our study, we employ glucose oxidase (GOx) as a glucose metabolism modulator to deplete glucose within the tumor microenvironment, initiating reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress and regulating both death receptor and mitochondrial apoptosis pathways, subsequently sensitizing HCC cells to DOX- induced apoptosis. DOX, co-formulated with GOx in nanoparticle (GOx-DOX-NP), not only substantially reduces tumor volume and increases number of apoptotic cells in tumors, but also acts as an immunogenic cell death (ICD) inducer, stimulating anti-tumor immunity. This effect further improves the immunotherapy. In conclusion, our findings underscore the potential of integrating glucose metabolism modulation with apoptosis-based therapies and immunotherapy for more effective liver cancer treatment.
Published in
Stimuli-Responsive Nanozyme Reprograms Tumor Immunometabolism and Overcomes Therapeutic Resistance in Hepatocellular Carcinoma
Ta YN, Nguyen VT, Can TT et al. · ACS nano 2026 · PMID 41493269 · doi:10.1021/acsnano.5c11352
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Also filed as BioProject PRJNA1255105 and SRA study SRP580988. Searching any of these in the dataset finder brings you back here.

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