Elevated Ozone Activates Maternal Immunity to Drive Offspring IgG-Mediated Anaphylaxis through IgG Glycosylation Reprogramming

The global burden of allergic diseases has reached alarming proportions and environmental factors exert a strong influence. Ozone (O3), with escalating pollution levels, has emerged as a critical and pressing environmental challenge worldwide and elicits pervasive oxidative stress among population. Epidemiological studies have linked prenatal oxidative stress to offspring allergy susceptibility, while existing evidence lacks causality.To address these gaps, correlation between hematological abnormalities in the retrospective mother-infant cohort and the daily O3 level was analyzed. Gestational MIA was induced via O3 exposure at environmentally relevant concentrations from embryonic day 9.5 (E9.5) onward, allowing for an in-depth examination of how neonatal IgG glycosylation is programmed.Using transcriptomic sequencing technologies, we further analyzed the subsequent effects on inflammatory pathways. Utilizing established allergic challenge models, long-term immune consequences in offspring were systematically evaluated, with a specific focus on elucidating the mechanistic role of glycosylated IgG in predisposing MIA progeny to allergic reactions.