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bulk RNAseq from the medial amygdala of male and female mice

GSE297014 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/06/25 Platform GPL24247
Summary
Sexual dimorphism in the brain is well-documented, yet clear binary features akin to genital differences remain elusive. Using the TRAP2 transgenic mouse line to track cFos-driven neuronal activity, we identified a distinct cluster of neurons (~200 µm) in the posterodorsal medial amygdala—termed the DIMPLE—that exhibited binary activation: consistently labeled in females but absent in adult virgin males. This pattern was unaffected by gonadectomy but was present in juvenile males before weaning and re-emerged in adult males after mating. Public RNA-seq data showed prolactin receptor enrichment in this region, and exogenous prolactin administration activated DIMPLE in virgin males. We propose that DIMPLE may support neural mechanisms related to female-typical behavior or paternal readiness.
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Also filed as BioProject PRJNA1262393 and SRA study SRP585075. Searching any of these in the dataset finder brings you back here.

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