Allergens Abrogate the Anti-inflammatory Property of DNA and Unmasks Macrophage/ILC2-STING-TNFα-driven Neutrophilic Asthma
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Mouse lung, Saline vs 3 × Mouse lung, Nucleosome vs 3 × Mouse lung, Alternaria vs 3 × Mouse lung, Alternaria + NucleosomeGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Allergens abrogate antiinflammatory DNA effects and unmask macrophage-driven neutrophilic asthma via ILC2/STING/TNF-α signalingThe Journal of clinical investigation · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297626_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1265491 and SRA study SRP586532. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8995877 Mouse lung, Saline 1 Mouse lung, Saline
- GSM8995878 Mouse lung, Saline 2 Mouse lung, Saline
- GSM8995879 Mouse lung, Saline 3 Mouse lung, Saline
- GSM8995880 Mouse lung, Nucleosome 1 Mouse lung, Nucleosome
- GSM8995881 Mouse lung, Nucleosome 2 Mouse lung, Nucleosome
- GSM8995882 Mouse lung, Nucleosome 3 Mouse lung, Nucleosome
- GSM8995883 Mouse lung, Alternaria 1 Mouse lung, Alternaria
- GSM8995884 Mouse lung, Alternaria 2 Mouse lung, Alternaria
- GSM8995885 Mouse lung, Alternaria 3 Mouse lung, Alternaria
- GSM8995886 Mouse lung, Alternaria + Nucleosome 1 Mouse lung, Alternaria …
- GSM8995887 Mouse lung, Alternaria + Nucleosome 2 Mouse lung, Alternaria …
- GSM8995888 Mouse lung, Alternaria + Nucleosome 3 Mouse lung, Alternaria …
- GSE235419 Deficiency of lncRNA MERRICAL abrogates macrophage chemotaxis and alleviates diabetes-associated atherosclerosis 11 samples shares macrophage, abrogate
- GSE319684 Timecourse of FACS sorted Ly6C+ monocytes, tissue resident alveolar macrophages (trAMs), monocyte derived alveolar macrophages (bmAMs) and epithelial cells from SARS-CoV-2 (maVie16) vs. IAV (PR8) infected mouse lungs 176 samples shares macrophage
- GSE269191 ZEB2 is a Master Switch Controlling the Tumor-Associated Macrophage Program [in vivo] 145 samples shares macrophage
- GSE300757 Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages 127 samples shares macrophage
- GSE280003 Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific programming in the lung 81 samples shares macrophage
- GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples shares macrophage
- GSE280514 Spatially-restricted and ontogenically-distinct hepatic macrophages are required for tissue repair. 48 samples shares macrophage
- GSE268774 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [RNA-seq] 48 samples shares macrophage
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.