Long non-coding RNAs Kcnq1ot1 and Lncpint are involved in skeletal muscle atrophy induced by the space exposome
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Long non-coding RNAs Kcnq1ot1 and Lncpint are involved in skeletal muscle atrophy induced by the space exposomeThe Journal of physiology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298607_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1270016 and SRA study SRP588888. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9018347 Sample 1, soleus muscle, control
- GSM9018348 Sample 2, soleus muscle, control
- GSM9018349 Sample 3, soleus muscle, control
- GSM9018350 Sample 4, soleus muscle, control
- GSM9018351 Sample 5, soleus muscle, control
- GSM9018352 Sample 6, soleus muscle, control
- GSM9018353 Sample 7, soleus muscle, control
- GSM9018354 Sample 8, soleus muscle, control
- GSM9018355 Sample 9, soleus muscle, control
- GSM9018356 Sample 10, soleus muscle, control
- GSM9018357 Sample 1, soleus muscle, space
- GSM9018358 Sample 2, soleus muscle, space
- GSM9018359 Sample 3, soleus muscle, space
- GSM9018360 Sample 4, soleus muscle, space
- GSM9018361 Sample 5, soleus muscle, space
- GSM9018362 Sample 6, soleus muscle, space
- GSM9018363 Sample 7, soleus muscle, space
- GSM9018364 Sample 8, soleus muscle, space
- GSM9018365 Sample 9, soleus muscle, space
- GSM9018366 Sample 10, soleus muscle, space
- GSE273878 Cancer-induced FOXP1 disrupts and reprograms skeletal muscle circadian transcription in cachexia [circadian RNA-seq] 48 samples shares skeletal, induced
- GSE325919 Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans 30 samples shares skeletal, induced
- GSE267909 Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance (bulk RNA-Seq) 14 samples shares involved, skeletal
- GSE326952 Semaglutide-induced Loss of Skeletal Muscle Mass is Blunted by Co-administration of Ketone Esters 13 samples shares skeletal, induced
- GSE267910 Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance (snRNA-Seq) 12 samples shares involved, skeletal
- GSE336537 Transcriptome changes driving multiple regulatory pathways involved in TGF-β-induced Anterior Subcapsular Cataract 10 samples shares involved, induced
- GSE294765 A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy 35 samples shares skeletal, atrophy
- GSE299587 Correlated protein-RNA associations and a requirement for HNRNPU in the long-range recruitment of Polycomb Repressive Complexes by the lncRNAs Airn and Kcnq1ot1 PLOS Genetics 40 samples shares kcnq1ot1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.