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Modulation of striatal cAMP levels: a paradigm shift in the treatment of hyperkinetic movement disorders

GSE298638 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/13 Platform GPL19057
Summary
Study of the striatal transcriptome consequences of a mutation of the ADCY5 gene, encoding the adenylyl cyclase 5 protein, an enzyme producing cAMP in the striatum. The Adcy5R419W mouse line was generated on a C57BL/6N background using CRISPR/Cas9-mediated genome editing. Mutations were introduced into exon 2 of the Adcy5 gene, located on chromosome 16. The c.1255C>T (p.R419W) substitution recapitulates the human p.R418W variant, accounting for the one-residue offset between mouse and human proteins.
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Also filed as BioProject PRJNA1271045 and SRA study SRP589405. Searching any of these in the dataset finder brings you back here.

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