Uncovering the Acetylation Sites of Dnmt3L to Regulate Protein Stability and Potency of Differentiation in Embryonic Stem Cells
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × ET vs 3 × Dnmt3L_WT vs 3 × Dnmt3L_K238 vs 3 × Dnmt3L_K412Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Uncovering the acetylation sites of Dnmt3L that regulate protein stability and differentiation potency in embryonic stem cellsExperimental & molecular medicine · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298928_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1271937 and SRA study SRP589798. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9026158 ET_1 ET
- GSM9026159 ET_2 ET
- GSM9026160 ET_3 ET
- GSM9026161 Dnmt3L_WT_1 Dnmt3L_WT
- GSM9026162 Dnmt3L_WT_2 Dnmt3L_WT
- GSM9026163 Dnmt3L_WT_3 Dnmt3L_WT
- GSM9026164 Dnmt3L_K238R_1 Dnmt3L_K238
- GSM9026165 Dnmt3L_K238R_2 Dnmt3L_K238
- GSM9026166 Dnmt3L_K238R_3 Dnmt3L_K238
- GSM9026167 Dnmt3L_K412R_1 Dnmt3L_K412
- GSM9026168 Dnmt3L_K412R_2 Dnmt3L_K412
- GSM9026169 Dnmt3L_K412R_3 Dnmt3L_K412
- GSE304392 Long-chain fatty acid β-oxidation regulates embryonic development by H3K18 acetylation in mice [CUT&Tag] 12 samples shares acetylation, embryonic, regulate
- GSE284312 Transfer RNA acetylation regulates in vivo mammalian stress signaling [tissues] 24 samples shares acetylation, regulate
- GSE245580 Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide [Chrom_RNAseq] 18 samples shares acetylation, regulate
- GSE245445 Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide [Chrom_RNAseq_iNOS1400W] 18 samples shares acetylation, regulate
- GSE76853 Acetyl-CoA metabolism by ACSS2 regulates neuronal histone acetylation and long-term memory [RNA-seq] 16 samples shares acetylation, regulate
- GSE308190 TIF1γ regulates stability of T regulatory cells during inflammation [RNA-seq] 15 samples shares stability, regulate
- GSE294457 TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency 12 samples shares acetylation, potency
- GSE279878 Mitochondrial fatty acid oxidation regulates monocytic type I interferon signaling via histone acetylation. 12 samples shares acetylation, regulate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.