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Transcriptome sequencing of liver injury models

GSE299455 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/30 Platform GPL24247
Summary
The liver is the largest solid organ and digestive gland in the human body. It plays a key role in the metabolism, transformation and detoxification of the three major organic substances. Therefore, the liver occupies an important place in the body's metabolism of substances. Crizotinib is a new type of drug with high efficiency for the treatment of lung cancer, but it has a large toxic effect, so this paper studies the acute effect of crizotinib on the liver, and studies its key targets for toxic effects through high-throughput transcriptome sequencing, which is divided into normal group and administration group, each group n=3, and the samples are mouse tissue samples.
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Direct links to NCBI, no account and no request form: the whole study as GSE299455_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1274471 and SRA study SRP591148. Searching any of these in the dataset finder brings you back here.

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