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Bulk RNA sequencing on hepatic tissues from colitis mice treated with a sublethal indirubin dose.

GSE299769 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/06/15 Platform GPL34290
Summary
Many plant-derived bioactive molecules with low solubility and permeability can cause hepatocyte injury. However, the mechanism by which they induce hepatic damage without passive diffusion into the hepatic circulatory system remains unclear. In this study, we demonstrate that indirubin, the main component of indigo naturalis with poor aqueous solubility, predisposes mice with chronic colitis to hepatic injury. This closely mimics the hepatic damage commonly observed in ulcerative colitis patients treated with indigo naturalis. To elucidate the mechanism of indirubin-induced hepatocyte injury in chronic colitis, we performed bulk RNA sequencing on hepatic tissues from DSS-induced colitis mice treated with a sublethal indirubin dose.
Published in
Macrophage-Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation
Xu Y, Shi J, Mok HL et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 40546113 · doi:10.1002/advs.202502993
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Also filed as BioProject PRJNA1276473 and SRA study SRP592070. Searching any of these in the dataset finder brings you back here.

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