GEO series
Transcriptional profiling of AGPS knockout breast cancer cells treated with TGF-B
GSE300281
Mus musculus
Expression profiling by high throughput sequencing
8 samples
2026/06/18
GPL17021
Summary
This study investigates the transcriptional changes associated with depleting ether lipids via AGPS (alkylglycerone phosphate synthase) knockout in epithelial PyMT-1099 murine breast cancer cells. RNA-Seq was performed to compare the gene expression profiles between AGPS knockout and control cells, both in the presence and absence of TGF-B treatment. The data provide insights into how ether lipid metabolism intersects with TGF-B-mediated signaling pathways and epithelial-to-mesenchymal transition (EMT) in breast cancer.
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