GEO series
FDX1-mediated cuproptosis promotes cholestaic liver injury exacerbated by taurocholic acid
GSE300382
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2026/01/14
GPL24247
Summary
As the primary route for copper elimination, cholestasis raises questions about the role of copper in cholestatic liver injury and its specific molecular mechanisms. Our findings reveal that cholestasis-induced copper overload drives liver injury via taurocholic acid (TCA) -exacerbated and FDX1-mediated cuproptosis.
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Paper (PMID 41513631) ↗
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