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Bulk RNA sequencing of kidneys from control and KC-Tie2 model of psoriasis

GSE300386 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/06 Platform GPL24247
Summary
Using a mouse model of psoriasis with Tie2 overexpression in keratinocytes (KC-Tie2) we compared transcriptomes of kidneys from these mice and littermate controls. We then performed bulk RNA sequencing of KC-Tie2 and littermate control kidneys at 10 weeks of age. Results revealed over-representation of gene ontology terms related to lupus and NETosis in KC-Tie2 kidneys. Together, these findings suggest that KC-Tie2 mice exhibit increased renal damage at least in part through enhanced neutrophil recruitment and NET formation.
Published in
G-CSF Mediates Increased Renal Neutrophils and Kidney Damage in a Psoriasis Mouse Model
Chen Z, Tessmer G, Nguyen BA et al. · Hypertension (Dallas, Tex. : 1979) 2025 · PMID 40905133 · doi:10.1161/HYPERTENSIONAHA.125.25111
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Also filed as BioProject PRJNA1280182 and SRA study SRP593488. Searching any of these in the dataset finder brings you back here.

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