← BioTransfer GEO Dataset Finder
GEO series

Bulk RNA-seq datasets supporting analysis of the MYC–USP10–SOX4 pathway in thymocytes and T-ALL

GSE300637 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/02/13 Platform GPL24247
Summary
This study presents bulk RNA-seq datasets generated from thymocytes of C57BL/6J mice to elucidate the transcriptional impact of thymus-specific loss of the deubiquitinase USP10. Total RNA was isolated from age-matched wild-type (WT) and USP10 conditional-knockout (USP10-cKO) thymus tissues, poly(A)+ fractions were enriched, and paired-end 150 bp libraries were sequenced on an Illumina NovaSeq 6000 platform. The resulting expression profiles allow direct comparison of global gene-expression programs between normal thymocyte development and USP10-deficient conditions, providing a resource for identifying USP10-regulated pathways, discerning stage-specific transcriptional alterations, and advancing our understanding of how ubiquitin signaling modulates early T-cell differentiation.
Published in
MYC-induced USP10 stabilizes SOX4 to promote thymocyte proliferation and leukemia onset in mice
Zhang M, Wu H, Lin X et al. · Nature communications 2026 · PMID 41927540 · doi:10.1038/s41467-026-71084-w
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE300637_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1280290 and SRA study SRP593599. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 7 more — browse all 7 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.