Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma [ATAC]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × Resource ATAC TM62 vs 3 × Resource ATAC TM71 vs 2 × Control ATAC TM62 vs 2 × Dexamethasone-treated ATAC TM62Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Chromatin dynamics identifies 78 genes at loci associated with elevated intraocular pressure and primary open-angle glaucomabioRxiv : the preprint server for biology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301516_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1285380 and SRA study SRP597556. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 3 samples read as cases, 3 as controls.
How we read this: 4 replicated groups read from 12 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9084566 Resource ATAC TM62 Rep1 Resource ATAC TM62
- GSM9084567 Resource ATAC TM62 Rep2 Resource ATAC TM62
- GSM9084568 Resource ATAC TM62 Rep3 Resource ATAC TM62
- GSM9084569 Resource ATAC TM71 Rep1 Resource ATAC TM71
- GSM9084570 Resource ATAC TM71 Rep2 Resource ATAC TM71
- GSM9084571 Resource ATAC TM71 Rep3 Resource ATAC TM71
- GSM9084572 Control ATAC TM62 Rep1 Control ATAC TM62
- GSM9084573 Control ATAC TM62 Rep2 Control ATAC TM62
- GSM9084574 Dexamethasone-treated ATAC TM62 Rep1 Dexamethasone-treated A…
- GSM9084575 Dexamethasone-treated ATAC TM62 Rep2 Dexamethasone-treated A…
- GSM9084576 Control ATAC TM70 Rep1
- GSM9084577 Dexamethasone-treated ATAC TM70 Rep1
- GSE301512 Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma [CUT&Run] 30 samples shares dexamethasone-treated, intraocular, trabecular, identifies, chromatin, topology, dynamics
- GSE301525 Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma 131 samples shares dexamethasone-treated, intraocular, trabecular, identifies, chromatin, topology, dynamics
- GSE271127 Substained DNA demethylation and discordant chromatin accessibility dynamics define enhancer regulation during neural progenitor cell differentiation [ATACme] 18 samples shares atac, chromatin, dynamics
- GSE291386 Chromatin accessibility profiling of HSPC-derived erythroblast differentiation [ATAC-seq] 165 samples shares atac, chromatin
- GSE318082 BAF complexes maintain accessibility at stimulus-responsive chromatin and are required for transcriptional stimulus responses [ATAC-seq] 63 samples shares atac, chromatin
- GSE282258 Imaging-based drug screening combined with moleuclar profiling identifies signatures and drivers of therapy resistance in pediatric AML [ATAC-seq] 44 samples shares atac, identifies
- GSE316389 Chromatin accessibility and gene expression profiling of primary and metastatic ER+ breast cancer [ATAC-seq] 36 samples shares atac, chromatin
- GSE264534 KAS-ATAC reveals the genome-wide single-stranded accessible chromatin landscape of the human genome 24 samples shares atac, chromatin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.