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Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma

GSE301525 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 131 samples Submitted 2026/04/10 Platform GPL30173
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 131 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Samples
131 samples: 29 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Chromatin dynamics identifies 78 genes at loci associated with elevated intraocular pressure and primary open-angle glaucomabioRxiv : the preprint server for biology · 2026
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Chromatin dynamics identifies 78 genes at loci associated with elevated intraocular pressure and primary open-angle glaucoma
Singh N, Batz Z, Advani J et al. · bioRxiv : the preprint server for biology 2026 · PMID 41890121 · doi:10.64898/2026.03.12.711121
This dataset
Open GSE301525 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301525_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1285372 and SRA study SRP597556. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41890121) ↗
Study design
29 conditions, mostly in triplicate
Control Total RNA TM62, ×4 Dex Total RNA TM62, ×4 Resource CUT&Run TM62 H3K4me ×3 Resource CUT&Run TM71 H3K4me ×3 Resource CUT&Run TM83 H3K4me ×3 Resource ATAC TM62 ×3 Resource ATAC TM71 ×3 Resource Total RNA TM62, ×3 +72 more

Supports a case/control comparison: 3 samples read as cases, 41 as controls.

How we read this: 29 replicated groups read from 131 sample titles; they account for 80 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 91 more — browse all 131 samples with per-sample file links →

Datasets on a similar topic

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Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.