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An Artemisia scoparia extract and rosiglitazone have distinct but overlapping effects on adipocyte function.

GSE302066 Mus musculus (mouse) RNA-seq (gene expression) 32 samples Submitted 2026/03/24 Platform GPL17021
At a glance

RNA-seq (gene expression) · mouse · 32 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
32 samples: 8 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
An Artemisia scoparia Extract and Rosiglitazone Have Distinct but Overlapping Effects on Adipocyte FunctionObesity (Silver Spring, Md.) · 2026
Summary (written by the submitters)
The effects of the PPAR-gamma agonist rosiglitazone (ROSI) on adipocyte gene expression have been extensively studied. Like ROSI, both SCO and a bioactive derivative, capillartemesin 7 (CAP7) inhibit lipolysis induced by the inflammatory cytokine TNF-alpha; they appear to do so through PPARg-dependent mechanisms that are overlapping but not identical to those engaged by ROSI.
Read the full summary ↓
To compare the transcriptional effects of SCO, CAP7, and ROSI, we performed a comparative gene expression profiling analysis of RNA-seq data from fully differentiated adipocytes that were treated with DMSO vehicle, SCO, CAP7, or ROSI, in the presence or absence of TNFa. Gene ontology and pathway analyses were performed to provide guidance for developing additional hypotheses to investigate mechanism of action underlying the ability of SCO and CAP7 to reduce TNFa-induced lipolysis and affect overall adipocyte function.
Published in
An Artemisia scoparia Extract and Rosiglitazone Have Distinct but Overlapping Effects on Adipocyte Function
Boudreau A, Yoo L, Harvey I et al. · Obesity (Silver Spring, Md.) 2026 · PMID 42015583 · doi:10.1002/oby.70196
This dataset
Open GSE302066 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE302066_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1288451 and SRA study SRP599180. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42015583) ↗
Study design
8 conditions, mostly with about 4 replicates each
basal_DMSO_Biol ×4 basal_SCO_Biol ×4 basal_CAP7_Biol ×4 basal_ROSI_Biol ×4 TNF_DMSO_Biol ×4 TNF_SCO_Biol ×4 TNF_CAP7_Biol ×4 TNF_ROSI_Biol ×4

Supports a between-group comparison across 32 samples.

How we read this: 8 replicated groups read from 32 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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