Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 5 × KO_Cort_MCAO vs 3 × KO_Cort_CL vs 3 × WT_Cort_CL vs 3 × WT_Cort_MCAOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemiaJournal of biomedical science · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE302342_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1290217 and SRA study SRP600080. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9102346 KO_Cort_CL_Rep1 KO_Cort_CL
- GSM9102347 KO_Cort_CL_Rep2 KO_Cort_CL
- GSM9102348 KO_Cort_CL_Rep3 KO_Cort_CL
- GSM9102349 KO_Cort_MCAO_Rep1 KO_Cort_MCAO
- GSM9102350 KO_Cort_MCAO_Rep2 KO_Cort_MCAO
- GSM9102351 KO_Cort_MCAO_Rep3 KO_Cort_MCAO
- GSM9102352 KO_Cort_MCAO_Rep4 KO_Cort_MCAO
- GSM9102353 KO_Cort_MCAO_Rep5 KO_Cort_MCAO
- GSM9102354 WT_Cort_CL_Rep1 WT_Cort_CL
- GSM9102355 WT_Cort_CL_Rep2 WT_Cort_CL
- GSM9102356 WT_Cort_CL_Rep3 WT_Cort_CL
- GSM9102357 WT_Cort_MCAO_Rep2 WT_Cort_MCAO
- GSM9102358 WT_Cort_MCAO_Rep3 WT_Cort_MCAO
- GSM9102359 WT_Cort_MCAO_Rep4 WT_Cort_MCAO
- GSE232098 Innate immune memory after brain injury drives inflammatory cardiac dysfunction 20 samples shares dysfunction, drives, brain
- GSE245987 Vascular endothelial S1PR2 aggravates cardiac ischemia/reperfusion injury through triggering mitochondrial dysfunctions and endothelial pyroptosis via RHO/ROCK1/DRP1/NLRP3 pathway [heart] 4 samples shares dysfunction, vascular, ischemia
- GSE98816 Single cell RNA-seq of mouse brain vascular transcriptomes 3186 samples shares vascular, brain
- GSE311449 Single cell RNA-seq of mouse brain vascular cells with Smart-seq2 method 391 samples shares vascular, brain
- GSE298799 Deconstructing the Intercellular Interactome in Vascular Dementia with Focal Ischemia for Therapeutic Applications 77 samples shares vascular, ischemia
- GSE297195 Age-dependent Transcriptional and Circuit Alterations in the brain Underlie Post-Anesthesia Neurobehavioral Dysfunction 66 samples shares dysfunction, brain
- GSE300113 Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer’s, CADASIL, and Traumatic Brain Injury (Main dataset) 59 samples shares vascular, brain
- GSE325692 Multi-omic analysis reveals brain-blood concordance and persistent neuroimmune reprogramming with stress and toxicant exposure in a mouse model of Gulf War Illness [RNA-Seq] 30 samples shares neuroimmune, brain
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.