Synergistic Multiple Effects of Resveratrol Combatting Salmonella Infection

This study investigates the host-directed therapeutic mechanism of resveratrol against Salmonella infection, a response to the escalating threat of antimicrobial resistance. The primary objective was to elucidate the global transcriptomic changes in host cells that underpin resveratrol's anti-pathogen efficacy. To achieve this, we performed RNA sequencing (RNA-seq) on murine macrophage-like RAW264.7 cells under four conditions: untreated control, resveratrol treatment alone, S. Typhimurium infection, and S. Typhimurium infection with concurrent resveratrol treatment. The goal of this transcriptomic analysis was to identify key host genes and cellular pathways that are manipulated by the pathogen during infection and subsequently modulated by resveratrol to clear the infection.