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Hepatocyte‑specific Ccnd1 knockout in aged mice reduces inflammatory signaling

GSE304265 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/08/13 Platform GPL34475
Summary
We performed hepatocyte‑specific knockout of Ccnd1 in 17‑month‑old C57BL/6J mice using AAV8‑TBG‑saCas9 with Ccnd1‑targeting sgRNA versus Rosa26 control. After 3 weeks, livers were harvested for bulk RNA‑seq to assess effects of elevated Ccnd1 with age.
Published in
Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline
Rajesh A, Havas AP, Arnold R et al. · bioRxiv : the preprint server for biology 2025 · PMID 40766702 · doi:10.1101/2025.08.01.668243
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Also filed as BioProject PRJNA1299809 and SRA study SRP605854. Searching any of these in the dataset finder brings you back here.

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