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RNA sequeqncing data of Kat6a–/–, Kat6a+/– and Kat6a+/+ E12.5 dorsal telencephalon and of Kat6a+/– and Kat6a+/+ E16.5 cortical neurons

GSE304794 Mus musculus (mouse) RNA-seq (gene expression) 20 samples Submitted 2026/02/03 Platform GPL19057
At a glance

RNA-seq (gene expression) · mouse · 20 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
20 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Acetyl-carnitine improves hyperactivity and learning deficits in KAT6A haploinsufficient miceLife science alliance · 2026
Summary (written by the submitters)
Mutation of one allele of the KAT6A gene encoding the histone acetyltransferase KAT6A (MOZ, MYST3) causes Arboleda-Tham-Syndrome (ARTHS), which is characterised by developmental delay, cognitive impairment and autism-like behaviours. We used mice to examine the effects of Kat6a mutations on gene expression in the develping cerebral cortex and cortical neurons.
Read the full summary ↓
We examined the effects of homozygous and heterozygous loss of Kat6a on gene expression in the E12.5 dorsal telecencephalon, the embryonic precursor of the cerebral cortex, and the effects of heterozygous loss of Kat6a on gene expression in foetal cortical neurons.
Published in
Acetyl-carnitine improves hyperactivity and learning deficits in KAT6A haploinsufficient mice
Eccles S, Vanyai HK, Bergamasco MI et al. · Life science alliance 2026 · PMID 41702672 · doi:10.26508/lsa.202503549
This dataset
Open GSE304794 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304794_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1302771 and SRA study SRP607251. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41702672) ↗
Study design
6 conditions, mostly in duplicate
Kat6a heterozygous, E16.5 cortical neurons, l… ×3 Wild Type, E12.5 dorsal telencephalon, litter… ×2 Wild Type, E16.5 cortical neurons, litter 367… ×2 Wild Type, E16.5 cortical neurons, litter 371… ×2 Kat6a heterozygous, E12.5 dorsal telencephalo… ×2 Kat6a homozygous, E12.5 dorsal telencephalon,… ×2 Wild Type, E12.5 dorsal telencephalon, litter… ×1 Wild Type, E12.5 dorsal telencephalon, litter… ×1 +5 more

Supports a between-group comparison across 13 samples.

How we read this: 6 replicated groups read from 20 sample titles; they account for 13 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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