← BioTransfer GEO Dataset Finder
GEO series

Effect of endostatin administration on epididymal white adipose tissue gene expression in female mice during the day.

GSE305072 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/04/08 Platform GPL24247
Summary
Endostatin is an endogenous cleavage product of Collagen 18 type a 1, an extracellular matrix protein that has anti-angiogenic properties. Increasing evidence suggests that endostatin has metabolic benefits in obesity models independently from its anti-angiogenic effects. Furthermore, multiple reports have shown drastic reduction in weight gain with endostatin treatment with high fat diet, and cell -autonomous effects of endostatin on adipocytes. The pathways that regulate endostatin 's effects on adipocytes are elusive. We have determined that there is a sex- and time-dependent effect of endostatin on adipose tissue gene expression. Therefore, we treated female mice with endostatin, collected adipose tissue and performed Total RNA-seq on RNA extracted from the tissue.
Published in
Timed secreted proteomes reveal regulation of hepatokines by the liver circadian clock
Litwin C, Zhang Q, Tsialtas I et al. · Nature communications 2026 · PMID 42230628 · doi:10.1038/s41467-026-73840-4
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE305072_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1304392 and SRA study SRP608006. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.