Hepatocyte-specific MET deletion exacerbates acetaminophen-induced hepatotoxicity in mice
Single-nucleus RNA-seq · mouse · 18 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue). Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hepatocyte-Specific MET Deletion Exacerbates Acetaminophen-Induced Hepatotoxicity in MiceThe American journal of pathology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE305543_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1306461 and SRA study SRP609098. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9179192 WT 0hr 1 WT 0h
- GSM9179193 WT 0hr 2 WT 0h
- GSM9179194 WT 0hr 3 WT 0h
- GSM9179195 KO 0hr 1 KO 0h
- GSM9179196 KO 0hr 2 KO 0h
- GSM9179197 KO 0hr 3 KO 0h
- GSM9179198 WT 6hr 1 WT 6h
- GSM9179199 WT 6hr 2 WT 6h
- GSM9179200 WT 6hr 3 WT 6h
- GSM9179201 KO 6hr 1 KO 6h
- GSM9179202 KO 6hr 2 KO 6h
- GSM9179203 KO 6hr 3 KO 6h
- GSM9179204 WT 24hr 1 WT 24h
- GSM9179205 WT 24hr 2 WT 24h
- GSM9179206 WT 24hr 3 WT 24h
- GSM9179207 KO 24hr 1 KO 24h
- GSM9179208 KO 24hr 2 KO 24h
- GSM9179209 KO 24hr 3 KO 24h
- GSE241165 Characterizing the gene expression profiles of 4T1 and 4T1.2 cells at different stages of bone metastsis using SMART-Seq2 technology 1248 samples shares met
- GSE311449 Single cell RNA-seq of mouse brain vascular cells with Smart-seq2 method 391 samples shares met
- GSE286046 Asymmetric Histone Inheritance Regulates Differential Transcription Re-initiation and Cell Fate Decisions in Mouse Olfactory Horizontal Basal Cells 96 samples shares met
- GSE319230 Metformin reduces RAN proteins and rescues molecular and behavioral phenotypes in SCA8 mice 12 samples shares met
- GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples shares met
- GSE302447 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity 67 samples shares met
- GSE311155 Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis 57 samples shares met
- GSE229238 DNA methylation constrains nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos [RNA-seq 2] 42 samples shares met
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.