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Dysregulated differentiation kinetics underlie essential role of DNA damage repair in cloned placentas [ChIP-Seq]

GSE305671 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2026/06/18 Platform GPL24247
Summary
To investigate the mechanisms underlying cloned placenta hyperplasia, we employed single-cell RNA and ATAC-seq multi-omics at the critical window of placental overgrowth. Our work offers the first comprehensive and novel single-cell–level dissection of developmental barriers in SCNT placentas, demonstrating that genomic instability constitutes the principal determinant of SCNT placental dysfunction, and outlines a feasible approach to improve reproductive cloning outcomes.
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Direct links to NCBI, no account and no request form: the whole study as GSE305671_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1307440 and SRA study SRP609791. Searching any of these in the dataset finder brings you back here.

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