Single-Nucleus Transcriptomics Reveals Cell Type-Specific Remodeling and Epilepsy Associated Microglia

In acquired epilepsy, an inciting injury is believed to trigger epileptogenesis, leading to dysfunctional networks that have both a propensity to give rise to seizures as well as impair normal cogntition. We have performed single nucleus sequencing on hippocampal tissue from a mouse model of temporal lobe epilepsy. The tissue was collected during time-points at which seizures and memory deficts are just begining to emerge. We anticipate this dataset will allow for the identification of key changes underlying epileptogenesis and provide candidates for therapeautic intervention.