Functional Role of THRAP3 in Modulating Thyroid Hormone–Mediated Gene Networks in C2C12 Myotubes
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × wild type C2C12 vs 3 × wild type C2C12 with T3 treatment vs 3 × Thrap3 KO C2C12 vs 3 × Thrap3 KO C2C12 with T3 treatmentGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Functional role of THRAP3 in modulating thyroid hormone-mediated gene networks in C2C12 myotubesPloS one · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE306461_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1310944 and SRA study SRP612716. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9201766 wild type C2C12_1 wild type C2C12
- GSM9201767 wild type C2C12_2 wild type C2C12
- GSM9201768 wild type C2C12_3 wild type C2C12
- GSM9201769 wild type C2C12 with T3 treatment_1 wild type C2C12 with T3…
- GSM9201770 wild type C2C12 with T3 treatment_2 wild type C2C12 with T3…
- GSM9201771 wild type C2C12 with T3 treatment_3 wild type C2C12 with T3…
- GSM9201772 Thrap3 KO C2C12_1 Thrap3 KO C2C12
- GSM9201773 Thrap3 KO C2C12_2 Thrap3 KO C2C12
- GSM9201774 Thrap3 KO C2C12_3 Thrap3 KO C2C12
- GSM9201775 Thrap3 KO C2C12 with T3 treatment_1 Thrap3 KO C2C12 with T3…
- GSM9201776 Thrap3 KO C2C12 with T3 treatment_2 Thrap3 KO C2C12 with T3…
- GSM9201777 Thrap3 KO C2C12 with T3 treatment_3 Thrap3 KO C2C12 with T3…
- GSE300503 Differentiation and Dexamethasone Atrophy on C2C12 myotubes 24 samples shares c2c12, myotubes
- GSE217125 Expression analysis of C2C12 cells treated with scramble siRNA or siRNA directed against Fndc1 10 samples shares c2c12
- GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples shares mediated
- GSE278534 EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization 76 samples shares mediated
- GSE334405 cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy 44 samples shares mediated
- GSE242179 Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification 40 samples shares mediated
- GSE247323 Maternal indole supplementation protects offspring from NAFLD through altered microbiota- and AHR-mediated ceramide metabolism 40 samples shares mediated
- GSE328134 Adipose tissue inflammation mediated by CCL19 overexpression exacerbates experimental periodontitis via elevated circulating saturated fatty acids and osteopontin in Western-diet-fed mice 36 samples shares mediated
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.