An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS [scRNA-Seq]
Single-cell RNA-seq · mouse · 18 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 × SOD1 end-stage, sample vs 6 × SOD1 mid-stage, sample vs 4 × Mixed SOD1 early-stage and control, sample vs 2 × Mixed SOD1 mid-stage and control, sampleGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE306676_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1311614 and SRA study SRP613728. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 4 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9205811 SOD1 end-stage, sample 1 SOD1 end-stage, sample
- GSM9205812 SOD1 end-stage, sample 2 SOD1 end-stage, sample
- GSM9205813 SOD1 end-stage, sample 3 SOD1 end-stage, sample
- GSM9205814 SOD1 end-stage, sample 4 SOD1 end-stage, sample
- GSM9205815 SOD1 end-stage, sample 5 SOD1 end-stage, sample
- GSM9205816 SOD1 end-stage, sample 6 SOD1 end-stage, sample
- GSM9205817 SOD1 mid-stage, sample 1 SOD1 mid-stage, sample
- GSM9205818 SOD1 mid-stage, sample 2 SOD1 mid-stage, sample
- GSM9205819 SOD1 mid-stage, sample 3 SOD1 mid-stage, sample
- GSM9205820 SOD1 mid-stage, sample 4 SOD1 mid-stage, sample
- GSM9205821 SOD1 mid-stage, sample 5 SOD1 mid-stage, sample
- GSM9205822 SOD1 mid-stage, sample 6 SOD1 mid-stage, sample
- GSM9205823 Mixed SOD1 mid-stage and control, sample 1 Mixed SOD1 mid-stage an…
- GSM9205824 Mixed SOD1 mid-stage and control, sample 2 Mixed SOD1 mid-stage an…
- GSM9205825 Mixed SOD1 early-stage and control, sample 1 Mixed SOD1 early-stage …
- GSM9205826 Mixed SOD1 early-stage and control, sample 2 Mixed SOD1 early-stage …
- GSM9205827 Mixed SOD1 early-stage and control, sample 3 Mixed SOD1 early-stage …
- GSM9205828 Mixed SOD1 early-stage and control, sample 4 Mixed SOD1 early-stage …
- GSE306675 An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS [multiome] 10 samples shares als, disease-associated, emergent, precedes, neuron, motor, state
- GSE335147 Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response 24 samples shares als, state
- GSE220675 Kidney Single-Cell Atlas Reveals Macrophage Heterogeneity in Progression and Regression of Cisplatin Induced AKI [scRNA-seq] 11 samples shares als, scrna-seq
- GSE294332 Multiomic single nuclei profiling of a mouse model of Alzheimer’s disease reveals that ACSS2 confers neuronal resilience to tauopathy 49 samples shares als, neuron
- GSE327428 GPR34 regulation of disease-associated microglial states in mice 96 samples shares disease-associated, state
- GSE227108 Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells (scRNA-seq) 18 samples shares scrna-seq, state
- GSE159911 “Bench-to-Bedside and Back” analysis of NAFLD model reveals common transcriptomic shifts between mouse and human during disease progression 152 samples shares als
- GSE225576 An atlas of the aging mouse transcriptome and proteome reveals the features of age-related post-transcriptional dysregulation 128 samples shares als
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.