ALDH2 inhibition reprograms tubular epithelial cell metabolism and promotes renal injury susceptibility
RNA-seq (gene expression) · mouse · 8 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 8 samples: 4 × WT primary TECs vs 4 × KO primary TECsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE306861_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1312710 and SRA study SRP614715. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 2 replicated groups read from 8 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9210940 WT primary TECs 1 WT primary TECs
- GSM9210941 WT primary TECs 2 WT primary TECs
- GSM9210942 WT primary TECs 3 WT primary TECs
- GSM9210943 WT primary TECs 4 WT primary TECs
- GSM9210944 KO primary TECs 1 KO primary TECs
- GSM9210945 KO primary TECs 2 KO primary TECs
- GSM9210946 KO primary TECs 3 KO primary TECs
- GSM9210947 KO primary TECs 4 KO primary TECs
- GSE284730 Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress 39 samples shares susceptibility, promotes
- GSE306012 Temporal inhibition of ADAM17 in fibroblasts reduces stiffness and promotes vascularization following myocardial infarction 28 samples shares inhibition, promotes
- GSE319252 Eicosapentaenoic Acid Reprograms Cerebrovascular Metabolism and Impairs Repair after Brain Injury, with Relevance to Chronic Traumatic Encephalopathy [mouse_brain_OnurE_RNA-seq] 12 samples shares reprograms, injury
- GSE289792 Inhibition of microglial SLC2A5 attenuates brain injury following acute ischemic stroke [RNA-Seq] 12 samples shares inhibition, injury
- GSE309904 Acute kidney injury following fatty liver ischemia-reperfusion injury: indirect protection by hepatic ferroptosis inhibition 12 samples shares inhibition, injury
- GSE311539 Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility (Bulk-RNAseq) 10 samples shares susceptibility, injury
- GSE337703 p300/CBP inhibition promotes apoptosis in mouse embryos by impairing H1K75ac-mediated DNA repair from the 4-cell to blastocyst stage 8 samples shares inhibition, promotes
- GSE327494 Localized PD-1 CAR T therapy reprograms neuroinflammation - mouse CAR T data. 302 samples shares reprograms
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.