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Integrative analysis reveals synergistic regulation of Sp7 by BRD9 and Wnt/β-catenin signaling during osteogenic differentiation

GSE308048 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/10/16 Platform GPL24247
Summary
Osteoporosis is a skeletal disorder involving low bone mineral density (BMD) and elevated fracture risk. While epigenetic mechanisms like DNA methylation are well-studied, the role of chromatin remodeling remains less clear. Using integrative genetics and functional studies, we identified BRD9—a non-canonical BAF subunit—as critical for osteoblast differentiation. BRD9 activates Wnt/β-catenin signaling and directly upregulates the key osteogenic factor Sp7. Our findings reveal a novel osteogenic role for BRD9 and suggest its potential as a biomarker and therapeutic target for bone-related diseases.
Published in
Integrative analysis reveals synergistic regulation of Sp7 by BRD9 and Wnt/β-catenin signaling during osteogenic differentiation
Wu L, Wang L, Zhuang Y et al. · Communications biology 2025 · PMID 41326797 · doi:10.1038/s42003-025-09278-z
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Also filed as BioProject PRJNA1328651 and SRA study SRP620437. Searching any of these in the dataset finder brings you back here.

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