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TNF-alpha–induced transcriptomic changes in three-dimensional engineered skeletal muscle (C2C12)

GSE309438 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/28 Platform GPL24247
Summary
Three-dimensional engineered skeletal muscle (C2C12) was used to examine transcriptomic changes induced by sustained TNF-α. Constructs received TNF-α (100 ng/mL, 72 h) or vehicle (n = 3/group), during which electrically evoked force declined under TNF-α. RNA-seq libraries were prepared with TruSeq Stranded mRNA and sequenced on an Illumina NovaSeq 6000 (PE 2×151 bp). Processed data include a gene-by-sample raw count matrix (raw_counts.tsv); raw FASTQ files are linked via SRA.
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Direct links to NCBI, no account and no request form: the whole study as GSE309438_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1336082 and SRA study SRP629460. Searching any of these in the dataset finder brings you back here.

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