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Gene expression profiling of cultured alveolar macrophages following induction of immunological cell death

GSE310184 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/01/12 Platform GPL24247
Summary
Alveolar macrophages (AMs) play a crucial role in protecting the lungs from pathogens by inducing immunogenic cell death (ICD). However, the type of cell death that effectively induces protective immunity remains to be fully understood. In our investigation of the mechanisms regulating AM activation and lung immune responses, we found that AMs are highly susceptible to necroptosis, a form of ICD. Treatment with pan-caspase inhibitor, emricasan, directly induced cell death in AMs, resulting in the release of interleukin 1α. To understand the characteristics of inflammatory responses induced by emricasan, we performed a comprehensive bulk RNA-seq analysis of cultured AMs treated with emricasan for 6 hours.
Published in
Resident alveolar macrophages are highly susceptible to the induction of RIPK1/RIPK3-mediated necroptosis which promote efficient pulmonary immune response
Adachi T, Matsushita K, Yasuda K et al. · Cell death & disease 2025 · PMID 41429777 · doi:10.1038/s41419-025-08372-8
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Also filed as BioProject PRJNA1365245 and SRA study SRP645408. Searching any of these in the dataset finder brings you back here.

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