RNA-seq data for studying the influence of fallopian tube stromal cells and/or estrogen treatment on fallopian tube epithilial cells

This study aims to investigate the role of fallopian tube (FT) stromal cells (SCs) in supporting the growth, proliferation and differentiation of fallopian tube epithelial (FTE) cells in response to estrogen signaling. Estrogen receptor alpha (encoded by Esr1) positive cells are present in both FTE and FT stromal compartments. Thus, estrogen exposure can affect FTE cells either directly or indirectly via Esr1+ SCs. Here we used RNA-seq expression profiling of murine FTE cells under various treatment conditions to demonstrate how estradiol (E2) treatment affected their transcriptomics directly, and indirectly via the co-cultured FT SCs, utilizing an organoid culture/co-culture system.