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Effect of HNF1A-MODY in glucagon expressing cells in the duodenal intestine [Bulk RNA-seq]

GSE311839 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/29 Platform GPL34290
Summary
This project investigates the impact of the Hnf1a hotspot mutation similar to HNF1A-MODY (Maturity-Onset Diabetes of the Young) on glucagon expressing cells in the intestine. RNA sequencing (RNA-seq) data was preformed on intestinal crypts isolated from duodenum from mutant and control Hnf1a mice to study the mutation's effect on gene expression. By comparing the transcriptomcis profiles of these crypts, the study aims to uncover molecular mehcnaisms underlying the phenotype caused by HNF1A-MODY during adulhood.
Published in
Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo
Unger L, Larsen U, Legøy TA et al. · Genes & development 2026 · PMID 41887801 · doi:10.1101/gad.353153.125
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Direct links to NCBI, no account and no request form: the whole study as GSE311839_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1370987 and SRA study SRP649781. Searching any of these in the dataset finder brings you back here.

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