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Decreased endothelial cell retinoic acid signaling accelerates progression of single ventricle pulmonary arteriovenous malformations

GSE312375 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/04 Platform GPL19057
Summary
To investigate transcriptomic changes in the endothelial cells of a mouse model of JP/HHT (Smad4), endothelial cells were isolated from the lungs of P5 Smad4 control (Smad4 conditional floxed mice; Smad4 f/f) and Smad4 HHT mice (Smad4 f/f;Cdh5-CreERT2). Data sets were compared to reveal differentially expressed genes that may provide clues into the molecular changes driving HHT phenotypes.
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Direct links to NCBI, no account and no request form: the whole study as GSE312375_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1373191 and SRA study SRP651053. Searching any of these in the dataset finder brings you back here.

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