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Bulk RNA Seq of Mouse RPE/Choroid from AAV-overexpressed IFN-beta and Control

GSE313587 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/04/01 Platform GPL24247
Summary
Type-I IFNs have been implicated in the development and progression of retinal disease, however the concequence of long term ocular exposure to Type-I IFN and the cell types that are impacted has not been characterized. This study uses AAV2 to overexpress IFN-beta to achieve prolonged retinal exposure with a single intravitreal injection. We have then employed a bulk RNA to examine the response of the RPE and choroidal cells to prolonged Type-I IFN exposure.
Published in
STING activation induces polarized cytokine secretion of IFN-β and IL-17A promoting photoreceptor death and choroidal disruption in age-related macular degeneration
Huang C, Babu VS, Bammidi S et al. · Cell death & disease 2026 · PMID 41760600 · doi:10.1038/s41419-026-08491-w
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Also filed as BioProject PRJNA1380354 and SRA study SRP654796. Searching any of these in the dataset finder brings you back here.

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